I wrote the research team and have skimmed the article. Dose regimen was 0.05mg/kg every other day. This would be about 0.25mg in an adult female human. Or about 0.25g of moderate potency cubensis. Half that or less of strong cubensis (PE/APE/etc).
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Was your dose frequency every other day?
I have a friend wanting to microdose and want her to be aware of your experience and possible withdrawal symptoms. The study used every other day which I would assume would minimize withdrawal considering psilocybin has a short half-life.
But I haven’t tried microing in years and when I did I only stuck with it for a week.
I microdosed for about 6 months and didn’t have any negative effects after stopping personally, but I used a different dosing schedule. I dosed every three days. The idea for that is to have a microdose day, an afterglow day, and finally a baseline day before repeating. I found this helpful both for tolerance, and also so you can compare your mood and experience to baseline even while you’re still on the regimen.
Cool, thanks for the info.
In the study the found no tolerance build up. I think having a day between is probably part of it for sure.
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Ahh… I’ve gone through SSRI withdrawal and I thought maybe something similar could be happening because of the repeated dosing.
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Yup. Was on venlafaxine and then duloxotine. Had to switch to Prozac and taper that.
It sucked.
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I have sat her a few times. Not a heroic dose yet but an eighth on three separate occasions.
She’s a bit hard to get to disengage. So she misses a lot of the experience talking etc. Plus she’s on Suboxone which I think might be coloring the experience. But we went for a walk in a nature preserve last time so at least I got her out in nature.
I’ve taken heroic doses a number of times. The first time definitely changed my perspective on life in a major way. I think it can be beneficial for people and could be beneficial for her. Just need to find the space and time to do it.
This only ever happened to me whenever I got REALLY high, I equate it to a drunken burp, people don’t really like them but I think they feel kind of good actually.
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This seems kind of silly to me. This is a drug that affects the brain, and that is nearly harmless at the microdose level. Just test on human volunteers. That way your results have useful clinical meaning. You can’t really ask the rats how they felt after the regimen.
They are, but placebo makes it difficult to measure.
This study proves more is going on then placebo and will surely help more funding go into human studies.
It’s certainly not silly. But I keep pet rats and I do find the methods used in animal studies often cruel. This one included.
But it’s not silly.
Yeah usually animal models are used because of danger to humans but we have plenty of evidence this substance is harmless.
Researcher: Hey, rodent, do you still have mental illness?
Rodent: Squeak Squeeeeeek
Researcher: What an astounding success!
