It modulates the response to the virus at the level of the immune system, and is used to treat an infection.
We conducted an experimental protocol with a nasal recombinant IFNα-2b formulation (Nasalferon) in 12 healthy volunteers who received 1 MIU per nostril twice a day, three consecutive days, and studied the induction of biomarkers related to antiviral and immune responses. Nasalferon increases the antiviral biomarker OAS1 transcript levels in oropharynx and PBMCs, regulates molecular and cellular elements related to innate and adaptive immune responses and decreases granulocytes population. These effects support Nasalferon use in virally-exposed populations.
Cuba will start applying Nasalferon to travelers and live-in family members
In Cuba, All International Travelers to Receive Nasalferon
Meanwhile “free” countries are destroying the lives of millions of people by pretending covid doesn’t exist anymore, and paxlovid is $1000 dollars and doctors don’t want to prescribe it because covid is “mild”.
When you have an economy that produces the highest number of doctors per capita and some of the lowest medical costs per capita.
:che-smiling:
But that’s actually a bad thing because the doctors aren’t super rich!
please cuba invade the united states and overthrow our despotic regime our people yearn for freedom
Interferon is named as such because when you have a virally infected cell, it will secrete it to interfere with the process. It knocks on the cell’s next door neighbor to say that shit’s fucked and you need to prepare. So the cell will close its windows, uptake less, etc. in an effort to be alert to stop the spread.
It still surprises me that you can do recombinant drugs without your body freaking out. Recombinant is when you put the gene (i.e. DNA) for interferon in an E. coli or yeast or something to harvest a bunch of it. The whole schtick of your immune system is deciding what’s foreign and what’s host. It’s like if a little alien knocked on your door and told you a different, mean alien is running around, so you need to lock your doors. You look at them in the eyes
, blink twice, and go “sure!”IIRC recombinant drugs are all based on human genes so the recomb proteins aren’t really “alien” though I like the rest of the analogy
Sure, you’re putting a human gene in there, but the subtle part of it is that when you have to recognize something as foreign, your cells chop up a protein and present IIRC 8-12 amino acids to present for immune cells (mhc-1). In that sense, the body is really sensitive to what proteins look like. I would imagine it not accepting a document that was .pdf instead of .docx. So when the protein is synthesized via recombinant means, I would expect some small change - if not even in terms of AA sequence (which Cuban scientists no doubt had to test for) then some glycosylation or other alterations that a bacteria would do.
The method isn’t brand new or anything, I believe insulin can be made that way (not checking), it’s just a marvel of science to me
You got me thinking about the different forms of insulin where sequence changes result in different effects… so yeah agreed it’s marvelous. Good point
This is where they were in 2021… Imagine what things could look like if everything wasn’t dictated by whether profit goes up or not.
Alright, so I’ll be making a trip to Cuba soon
Yeah, how do you go to Cuba? Need to go now
iirc it’s actually not that hard as an American? I think you have to state your purpose for visiting Cuba, and you check off the box that says “support of the Cuban people”? Might be other stuff but I think it’s not actually that hard. There are also some leftist groups which take people down there
“You want to go to Cuba? For sexpat reasons?”
“Yeeeees”
actually supports the Cuban people like a boss
That was true back when Obama was in office (my mom, my sister, and I did just that), but I think it’s different now. I think we’re back to a situation where american citizens aren’t technically allowed to go visit Cuba. You still can, but I think you have to get there via Mexico these days.
No, this is wrong, you can fly via Miami still.
Oh, that’s good! I really did think it had changed. I’m glad to be wrong!
Go to a third country. Try to hitch a ride on a boat to Cuba. Hope they stamp a separate piece of paper instead of your passport so the tyrannical Biden regime doesn’t send you to jail
You go to the Bahamas, get stamped there, then boat to Cuba. Cuban officials don’t stamp American passports. Then when you go back to the US they think you went to the bahamas.
That’s how it was in the early aughts at least
That sounds amazing. Even moreso considering you’d be sneaking around on the USA 😏
Not necessarily true anymore.
My American passport was stamped in cuba
Was that Obama years? Wonder if it changed after that
This is maybe last resort, but you can take a cruise ship there. As long as the boat is in the port, you don’t need a passport to spend less than 24 hours in Cuba. It’s how a lot of Americans do it.
But it would mean going on a cruise ship
going on a cruise ship
If your intent is to avoid being loaded with viruses, this may be self-defeating.
Join a socialist delegation. Most good orgs will have a relationship with Cuba. You will usually be able to spend a week or so there as a group.
You’ll be shuttled around but can get free time if you organize it.
Their vaccines have also been very effective
Meanwhile “free” countries are destroying the lives of millions of people by pretending covid doesn’t exist anymore
well, why would they want to eradicate a virus that they created?
stupid capitalist I’m ballinCuba pound-for-pound best country.
Quarantine and the occasional lockdowns would be less harmful than that level of use of interferons
I don’t know anything about interferons. What effects do those have that other vaccines don’t?
These is at a higher dose but gives you a sense:
Although frequently effective, IFNα induces a variety of neuropsychiatric adverse effects, including an acute confusional state that develops rapidly after initiation of high-dose IFNα, a depressive syndrome that develops more slowly over weeks to months of treatment, and manic conditions most often characterised by extreme irritability and agitation, but also occasionally by euphoria. Acute IFNα-induced confusional states are typically characterised by disorientation, lethargy, somnolence, psychomotor removedation, difficulties with speaking and writing, parkinsonism and psychotic symptoms. Strategies for managing delirium should be employed, including treatment of contributing medical conditions, use of either typical or atypical antipsychotic agents and avoidance of medications likely to worsen mental status. Significant depressive symptoms occur in 21–58% of patients receiving IFNα, with symptoms typically manifesting over the first several months of treatment. The most replicated risk factor for developing depression is the presence of mood and anxiety symptoms prior to treatment.
A vaccine trains your immune system to respond, and interferon therapy is throwing the immune system into DEFCON 1
Useful and an achievement for Cuba but still worse than other social interventions
They are using it to treat infections.
Not sure what they are doing to treat cases these days, but after they rolled out their RBD vaccines to everyone in 2021 cases and deaths flatlined.
Cases would exhibit some seasonality instead of going to zero for years of new variants
This is not unique to Cuba of course
And of course, even China eventually succumbed to “letting it rip” instead of eradication which was, at one point, actually feasible.
I suppose ‘feasible’ is a subjective word, but eradication is still possible, and is a proletarian aim. China was being sadly ahead of it’s time, but in so doing showed the world a model for it
